热带海洋学报 ›› 2022, Vol. 41 ›› Issue (5): 189-193.doi: 10.11978/2021186

• 海洋生物学 • 上一篇    

深海热液真菌Fusarium sp. SCSIO 06196中抗病毒聚酮类化学成分研究

王俊锋1, 周雯颖2, 田新朋1, 刘永宏1()   

  1. 1.中国科学院南海海洋研究所, 热带海洋生物资源与生态重点实验室, 广东 广州 510301
    2.广州中医药大学, 第五临床医学院, 广东 广州 510405
  • 收稿日期:2021-12-30 修回日期:2022-03-01 出版日期:2022-09-10 发布日期:2022-03-21
  • 通讯作者: 刘永宏

Antiviral chromones from the deep-sea hydrothermal-vent-derived Fusarium sp. SCSIO 06196

WANG Junfeng1, ZHOU Wenying2, TIAN Xinpeng1, LIU Yonghong1()   

  1. 1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
    2. Fifth School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
  • Received:2021-12-30 Revised:2022-03-01 Online:2022-09-10 Published:2022-03-21
  • Contact: LIU Yonghong
  • Supported by:
    Science and Technology Project of Hainan Province(ZDKJ202018);National Natural Science Foundation of China(21502204);National Natural Science Foundation of China(41776169)

摘要:

从西太平洋深海热液沉积物来源的镰刀菌SCSIO 06196中分离鉴定了6个色原酮类化合物(1~6), 通过核磁共振光谱、质谱及旋光等多种分析测试方法确定了色原酮类化合物的结构。抗病毒活性筛选发现, 化合物1~3展示出显著的抗肠道病毒EV-71活性, IC50分别达到26.7μmol•L-1、19.8μmol•L-1和22.0μmol•L-1 (阳性对照药物利巴韦林为177μmol•L-1)。此外, 化合物1还显示出弱的抗流感病毒H3N2活性, IC50为8.6μmol•L-1 (阳性对照药物达菲为18.5nmol•L-1)。

关键词: 深海热液, 聚酮, 抗肠道病毒活性, 抗流感病毒活性

Abstract:

Six chromone derivatives (1 ~ 6) were identified from the fungus Fusarium sp. SCSIO 06196 isolated from deep-sea hydrothermal vent environments in the Western Pacific. Their structures were elucidated mainly by extensive Nuclear Magnetic Resonance (NMR) spectroscopic, mass spectrometric (MS) and rotational analysis. Antiviral activities of the compounds 1 ~ 6 were tested. Among these compounds, compounds 1 ~ 3 exhibited significant in vitro anti-enterovirus 71 (EV-71) activities with IC50 values of 26.7, 19.8, and 22.0 μmol•L-1, respectively (IC50=177 μmol•L-1, Ribavirin). In addition, compound 1 showed weak antiviral activity against the H3N2 influenza virus with IC50 value of 8.6 μmol•L-1 (IC50=18.5 nmol•L-1, Tamiflu).

Key words: deep-sea hydrothermal vent, polyketide, anti-EV 71 activity, anti-H3N2 activity

中图分类号: 

  • P735.4