海洋生物资源

海洋真菌来源吲哚生物碱类化合物的结构和活性研究

  • 李庆欣 ,
  • 史雪凤 ,
  • 黄智 ,
  • 田新朋 ,
  • 王发左
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  • 中国科学院南海海洋研究所, 中国科学院海洋生物资源可持续利用重点实验室, 中国科学院海洋微生物研究中心, 广东省海洋药物重点实验室,广东 广州 510301
李庆欣(1951—), 男, 广东省兴宁市人, 工程师, 主要从事海洋生物资源及其利用研究。E-mail: liqx81@163.com

收稿日期: 2013-04-20

  修回日期: 2013-04-20

  网络出版日期: 2013-04-20

基金资助

国家自然科学青年基金(40906076、40906075);国家重点基础研究发展计划(973)项目(2010CB833800);中国科学院知识创新工程重要方向项目(KSCX2-YW-G-073);财政部战略生物资源科技支撑运行专项项目(KSCX2-YW-Z-1018)

Indole alkaloids from marine-derived fungi: structures and activities

  • LI Qing-xin ,
  • SHI Xue-feng ,
  • HUANG Zhi ,
  • TIAN Xin-peng ,
  • WANG Fa-zuo
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  • Key Laboratory of Marine Bio-resources Sustainable Utilization, Research Network for Applied Microbiology (RNAM) Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

Received date: 2013-04-20

  Revised date: 2013-04-20

  Online published: 2013-04-20

摘要

近年来,海洋真菌因其能够产生大量结构新颖、活性显著的代谢产物而受到广泛关注。本文综述了1991—2010年间从海洋真菌分离得到的134个新吲哚生物碱的结构和活性研究情况,其中包括fumitremorgin类19个、notoamide类22个、细胞松弛素类18个、吲哚喹唑啉类9个、吲哚萜类11个、肽类及其他单吲哚类21个和双吲哚类化合物34个。海洋真菌来源的吲哚生物碱不仅结构奇特,并且表现出多种重要的生物活性,具有潜在的研究和应用价值。

本文引用格式

李庆欣 , 史雪凤 , 黄智 , 田新朋 , 王发左 . 海洋真菌来源吲哚生物碱类化合物的结构和活性研究[J]. 热带海洋学报, 2013 , 32(1) : 35 -47 . DOI: 10.11978/j.issn.1009-5470.2013.01.005

Abstract

In recent years, marine natural products of fungal origin have gained considerable recognition, as many of them possess novel structures and interesting biological and pharmacological properties. This review includes 134 indole alkaloids of marine-derived fungi with their structures and activities published during 1991-2010. Of the indole alkaloids, there were 19 fumitremorgins, 22 notoamides, 18 cytochalasans, 9 fumiquinazolines, 11 indole terpenes, 21 peptides and other single indole alkaloids, and 34 bisindole alkaloids. These indole alkaloids showed not only unique structures but also a variety of important biological activities and had potential values in application.

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