本文旨在研究北部湾软珊瑚共附生真菌Scopulariopsis sp. SCSIO 41229的次级代谢产物。采用正相硅胶柱层析、反相硅胶柱层析、薄层色谱、高效液相色谱等多种方法对该菌株的发酵产物进行分离纯化， 通过核磁共振、质谱等波谱学方法并结合理化性质， 文献数据比对对其进行结构鉴定。从中分离得到9个化合物， 分别为neocyclocitrinols A–D (1~4)、penicillenol A2 (5)、 环(D-苯丙-L-异亮)二肽 (6)、 cyclo-(L-tryptophyl-L-phenylalanyl) (7)、 2-(hept-5-enyl)-3-methyl-4-oxo-6,7,8,8a-tetrahydro-4H-pyrrolo [2,1-b]-1,3-oxazine (8)和 (8E,10E)-7-oxo-8,10-heptadecadienoic acid (9)。生物活性测试显示， 化合物2和4 具有弱抗氧化活性， 化合物1、 4和8 具有弱乙酰胆碱酯酶抑制活性。化合物1~9均为首次从Scopulariopsis sp.真菌中分离得到。

In this study, we aim to investigate the secondary metabolites from the coral-derived fungus Scopulariopsis sp. SCSIO 41229, which were collected from the Beibu Gulf. The secondary metabolites were isolated by silica gel column chromatography, reverse phase silica gel column chromatography, thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC). The chemical structures of these compounds were identified by nuclear magnetic resonance (NMR), mass spectrometry (MS) and literature analysis. Nine known compounds were isolated and elucidated as neocyclocitrinols A–D (1~4), penicillenol A2 (5), cyclo-(D-Phe-L-Ile) (6), cyclo-(L-tryptophyl-L-phenylalanyl) (7), 2-(hept-5-enyl)-3-methyl-4-oxo-6,7,8,8a-tetrahydro-4H-pyrrolo[2,1-b]-1,3-oxazine (8), (8E,10E)-7-oxo-8,10-heptadecadienoic acid (9). Bioassays indicated that compounds 2, 4 had weak antioxidant activity and compounds 1, 4, 8 showed weak inhibitory activity against acetylcholin esterase. Compounds 1~9 were obtained from the fungus Scopulariopsis sp. for the first time.