骨关节炎（Osteoarthritis，OA）是一种慢性关节退行性疾病，其特征是关节软骨逐渐丧失和关节结构的破坏。本文研究了海参肽在抗骨关节炎（OA）中的潜在作用，通过计算机模拟胃肠道酶解过程和在线数据库预测，筛选出海参蛋白中的活性肽段。结合网络药理学、分子对接和量子化学计算，虚拟筛选得出一条具有较强抗OA活性的海参候选肽（FDPVIEEYHNGF）。进一步的分析揭示，该肽可能通过调节IL-17和TNF信号通路，抑制炎症反应、胶原降解以及基质金属蛋白酶（MMPs）的活性，缓解OA。海参肽可能与OA的潜在核心靶点MMP9、IL -17RA形成氢键，进而影响相关信号通路，减少炎症反应，干预细胞外基质重塑，减轻对胶原的破坏。本研究为海参肽作为功能性食品成分应用于骨关节炎的食品开发提供了新的思路。

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the progressive loss of articular cartilage and the destruction of joint structures. This study investigates the potential role of sea cucumber peptides in treating OA. Through computer simulations of gastrointestinal digestion and online database predictions, bioactive peptides from sea cucumber protein were identified. Using network pharmacology, molecular docking, and quantum chemical calculations, a sea cucumber peptide candidate (FDPVIEEYHNGF) with strong anti-OA activity was virtually screened. Further analysis suggests that this peptide may alleviate OA by modulating the IL-17 and TNF signaling pathways, inhibiting inflammation, collagen degradation, and the activity of matrix metalloproteinases (MMPs). The sea cucumber peptide may form hydrogen bonds with MMP9 and IL-17RA, a potential core target for OA, thereby influencing the related signaling pathways, reducing inflammation, intervening in extracellular matrix remodeling, and mitigating collagen degradation. This study provides new insights into the application of sea cucumber peptides as functional food ingredients in the development of therapeutic foods for OA.