海洋微生物来源天然产物研究现状与态势

doi:10.11978/2020104

热带海洋学报 ›› 2021, Vol. 40 ›› Issue (5): 134-146.doi: 10.11978/2020104CSTR: 32234.14.2020104

海洋微生物来源天然产物研究现状与态势

马丽丽^1,²(), 田新朋³, 李桂菊^1,², 赵晏强^1,², 殷建平³()

1.中国科学院武汉文献情报中心, 湖北武汉 430071
2.科技大数据湖北省重点实验室, 湖北武汉 430071
3.中国科学院南海海洋研究所, 广东广州 510301

收稿日期:2020-09-15 修回日期:2021-01-19 出版日期:2021-09-10 发布日期:2021-02-16
通讯作者: 殷建平
作者简介:马丽丽(1989—), 女, 河北省南宫市人, 副研究馆员, 博士, 从事学科情报研究与科学数据管理研究。email: mall@mail.whlib.ac.cn
基金资助:
中国科学院战略性先导科技专项(XDA13000000);中国科学院文献情报能力建设专项子项目(Y9KZ411)

Research status and development trends of natural products from marine microorganisms

MA Lili^1,²(), TIAN Xinpeng³, LI Guiju^1,², ZHAO Yanqiang^1,², YIN Jianping³()

1. Wuhan Library of the Chinese Academy of Sciences, Wuhan 430071, China
2. Hubei Key Laboratory of Big Data in Science and Technology, Wuhan 430071, China
3. South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

Received:2020-09-15 Revised:2021-01-19 Online:2021-09-10 Published:2021-02-16
Contact: YIN Jianping
Supported by:
Strategic Priority Research Program of the Chinese Academy of Sciences(XDA13000000);Construction of Document and Information Capacity of Chinese Academy of Sciences Special Supporting Item Sub-project(Y9KZ411)

摘要/Abstract

摘要：

海洋微生物因长期适应特殊的生存环境而进化出特殊的代谢途径, 从而产生大量结构新颖、功能独特的生物活性物质, 使海洋微生物来源的天然产物成为海洋新药开发的研究热点。文章以文献计量学的方法和视角, 从海洋真菌和海洋细菌天然产物研究现状、海洋微生物天然产物的人工合成、海洋微生物天然产物的生物活性评估以及成药性评价等方面进行概述, 分析了当前海洋微生物天然产物状况和发展态势。

关键词: 海洋微生物, 天然产物, 海洋药物, 生物合成, 生物活性评估

Abstract:

Because of their unique habitat and metabolic pathways, marine microorganisms can produce a variety of bioactive substances with novel structures and functions, which make natural products from these marine microorganisms become a research hotspot of new marine drugs. Combining the methods and perspectives of bibliometrics, we review in this paper the research status of natural products from marine fungi and marine bacteria, the artificial synthesis of natural products of marine microorganisms, the biological activity and druggability evaluation of natural products from marine microorganisms, to clarify the current status and development trend of natural products from marine microorganisms.

Key words: marine microorganism, natural product, marine drug, biosynthesis, biological activity evaluation

中图分类号:

P745.3

马丽丽, 田新朋, 李桂菊, 赵晏强, 殷建平. 海洋微生物来源天然产物研究现状与态势[J]. 热带海洋学报, 2021, 40(5): 134-146.

MA Lili, TIAN Xinpeng, LI Guiju, ZHAO Yanqiang, YIN Jianping. Research status and development trends of natural products from marine microorganisms[J]. Journal of Tropical Oceanography, 2021, 40(5): 134-146.

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海洋微生物来源天然产物研究现状与态势

Research status and development trends of natural products from marine microorganisms

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	关键词	词频		关键词	词频
1	marine fungi	285	16	anticancer	33
2	Antibacterial activity	218	17	apoptosis	33
3	marine bacteria	157	18	drug discovery	29
4	cytotoxicity	131	19	Biofilm	28
5	Marine actinomycetes	131	20	genome mining	25
6	bioactivity	78	21	total synthesis	25
7	Streptomyces sp.	77	22	Diketopiperazine	21
8	antibiotics	55	23	antitumor	19
9	biosynthesis	52	24	metabolomics	19
10	antifungal activity	51	25	antioxidant	18
11	Marine sponge	51	26	pharmacology	18
12	polyketide	48	27	synthesis	17
13	Antifouling	42	28	biosynthetic gene cluster	16
14	alkaloids	41	29	peptides	16
15	structure elucidation	38	30	Polyketide synthase	16

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