海绵共附生真菌；Penicillium crustosum；次级代谢产物；抗氧化；抗菌," /> 海绵共附生真菌；Penicillium crustosum；次级代谢产物；抗氧化；抗菌,"/> 海绵共附生真菌Penicillium crustosum SCSIO 41442活性代谢产物研究
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海绵共附生真菌Penicillium crustosum SCSIO 41442活性代谢产物研究

梁嘉琦1, 2, 陈欣琪1, 2, 陈仪1, 2, 丛梦静1, 曹沁琳1, 黄晓雯1, 3, 刘永宏1, Jayasinghe Lalith 1, 4, 陈春梅1, 周雪峰1, 2   

  1. 1. 中国科学院热带海洋生物资源与生态重点实验室, 广东省海洋药物重点实验室, 中国科学院南海海洋研究所, 广东 广州 510301;

    2. 中国科学院大学, 北京 100049;

    3. 桂林医学院, 广西 桂林541199;

    4. 国家基础科学研究所, 康提 斯里兰卡

  • 收稿日期:2025-02-18 修回日期:2025-03-19 接受日期:2025-03-25
  • 通讯作者: 陈春梅
  • 基金资助:

    广东省自然资源厅海洋经济发展专项(GDNRC[2023]37)

Bioactive Metabolites from the Sponge-Derived Fungus Penicillium crustosum SCSIO 41442

LIANG Jiaqi1, 2, CHEN Xinqi1, 2, CHEN Yi1, 2, CONG Mengjing1, CAO Qinlin1, HUANG Xiaowen1, 3, LIU Yonghong1, JAYASINGHE Lalith1, 4, CHEN Chunmei1, ZHOU Xuefeng1, 2   

  1. 1. CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;

    2. University of Chinese Academy of Sciences, Beijing 100049, China;

    3. Pharmacy school of Guilin Medical University, Guilin 541199, China;

    4. National Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka

  • Received:2025-02-18 Revised:2025-03-19 Accepted:2025-03-25
  • Supported by:
    Special Project for Marine Economic Development of Department of Natural Resources of Guangdong Province(GDNRC[2023]37)

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摘要：

从海绵共附生真菌Penicillium crustosum SCSIO 41442中分离得到1个新生物碱diacedolinate（1）和14个已知化合物（2~15）。通过光谱学分析和电子圆二色谱（ECD）测定了所有化合物的结构，并对这些化合物进行了抗氧化和抗菌活性测试。结果表明，化合物1具有弱抗氧化活性，半抑制浓度（IC50, half maximal inhibitory concentration）为 (71.00±0.14)μg·mL-1.。与阳性对照维生素C相比，化合物2表现出强抗氧化活性，IC50为 (1.25±0.10) μg·mL-1。化合物9、10、11和15对耐甲氧西林葡萄球菌（methicillin-resistant Staphylococcus aureus, MRSA）、Colletotrichum asianum HNM 408, Colletotrichum acutatum HNM RC178 和 Alternaria alternate多种病原菌表现出广谱的抗菌活性，最小抑菌浓度（MIC, minimum inhibitory concentration）为2.5~160 μg·mL-1.。这些化合物的活性均为首次报道。

关键词:

海绵共附生真菌；Penicillium crustosum；次级代谢产物；抗氧化；抗菌')">"> 海绵共附生真菌；Penicillium crustosum；次级代谢产物；抗氧化；抗菌

Abstract: A new alkaloid, diacedolinate (1), together with 15 known compounds (2–16) were isolated from sponge–associated fungus Penicillium crustosum SCSIO 41442. The structure of these compounds was determined by spectrum analysis and ECD (electronic circular dichroism). All compounds were tested for their antioxidant and antimicrobial activities. As the result, compound 1 showed remarkable antioxidant activity with IC50 (half maximal inhibitory concentration) value of 71.00 μg/mL. Compound 2 displayed extensive antioxidant activity with IC50 value of 1.25 μg/mL, compared with the positive control, Vitamin C. In addition, compounds 9, 10, 11 and 16 demonstrated broad antimicrobial activity against a variety of pathogens, including MRSA (methicillin-resistant Staphylococcus aureus), Colletotrichum asianum HNM 408, Colletotrichum acutatum HNM RC178 and Alternaria alternate, with MIC (minimum inhibitory concentration) values between 2.5 and 160 μg/mL. The activity of these compounds was reported for the first time.

Key words: sponge-derived fungi, Penicillium crustosum, secondary metabolites, antioxidant, antimicrobial