水母共附生真菌Aspergillus fumigatus SCSIO41214中生物碱类化合物研究

doi:10.11978/2022193

Journal of Tropical Oceanography ›› 2023, Vol. 42 ›› Issue (4): 195-201.doi: 10.11978/2022193CSTR: 32234.14.2022193

• Exploitation of Marine Resources • Previous Articles

Alkaloids from the Jellyfish-Derived Fungus Aspergillus fumigatus SCSIO41214

YANG Bin(), SALENDRA Limbadri, LIU Juan, LIU Yonghong()

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

Received:2022-09-16 Revised:2022-10-08 Online:2023-07-10 Published:2022-10-13
Supported by:
National Natural Science Foundation of China(21977102); Guangdong-Joint Foundation of Shenzhen(2021B1515120046)

Abstract

Abstract:

Eight known alkaloids were isolated from jellyfish-derived fungus Aspergillus fumigatus SCSIO41214. These compounds were isolated by silica gel column chromatography, ostade-cylsilane (ODS), and high performance liquid chromatography (HPLC). The structure of 1 was identified by performing a comprehensive analysis of spectroscopic data and X-ray diffraction for the first time. The structures of 2 ~ 8 were elucidated by spectroscopic methods and by comparison with data from the literature. In bioassay, compound 4 showed weak inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) in RAW264.7 cells at the concentration of 10 μmol·L^-1.

Key words: jellyfish, Aspergillus fumigatus SCSIO41214, alkaloid

YANG Bin, SALENDRA Limbadri, LIU Juan, LIU Yonghong. Alkaloids from the Jellyfish-Derived Fungus Aspergillus fumigatus SCSIO41214[J].Journal of Tropical Oceanography, 2023, 42(4): 195-201.

Figures/Tables 2

References 16

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Alkaloids from the Jellyfish-Derived Fungus Aspergillus fumigatus SCSIO41214

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