The Zhujiang River Estuary, the most active region in China's economic development, is experiencing rapid urbanization and industrialization, of which effective sustainable use of the funding sources becomes an ultimate goal to develop and utilize space technology and resources. In this article the authors mined and extracted the farming information with the same spatial scale and precision based on the analysis of data from the three-phase multi-source remote sensing information of the Zhujiang River Estuary and conventional survey with classification system and spatial accuracy consistency, to introduce the model of single land use dynamic index, the landscape fragmentation, and multi-model analysis of spatial information such as changes in the distribution area statistics and the gravity center. Quantified results show that from 1985 to 2005 aquaculture area increased from 125.49km2 to 345.20km2, 2.75 times as large as that in 1985. The average annual growth rate of aquaculture area was 14.30% between 1985 and 1995, and dropped to 1.32% after 1995. In the past 20 years from 1985 to 2005, the fragmentary degree of aquaculture area gradually increased from 0.000015 to 0.002824. The change of aquaculture area presented regional differences for the five cities in the Zhujiang River Estuary. The growth rate in Guangzhou, Dongguan and Zhuhai City kept going up, with quite large difference among them; but for Zhongshan and Shenzhen, the growth rate dropped after a period of increment. Comprehensive analysis leads to the conclusion that the gravity center of the aquaculture area migrated to the northwest in the whole.