Using ADCP （Acoustic Doppler Current Profiler） and CTD (Conductivity/Temperature/Depth profiler) data acquired in August 2007 and the Gregg model, the authors estimate the internal-wave-scale mixing in the intermediate and deep layers of the South China Sea. They also use the Thorpe scale to study the vertical overturns in these layers and the corresponding diapycnal diffusivity. The results by the two methods are consistent, showing that the dissipation rate and diapycnal diffusivity in the upper 400m near the Luzon Strait are larger than those at 18°N, while there is no obvious distinction in the mediate and deep layers. These results, therefore, suggest that there may be active internal waves resulting in intensive internal wave mixing and vertical overturning in the upper 400m near the Luzon Strait. The dissipation rate and diapycnal diffusivity estimated by the Gregg model are at the level of 10–9 W?kg–1 and 10–6 m2?s–1, respectively. At most of the CTD stations surveyed, there always exists vertical overturning in the intermediate and deep layers and the diapycnal diffusivity estimated by the Thorpe scale does not decrease with depth. The characteristics of the fine-scale mixing reported here will facilitate the understanding of the intermediate and deep layers of the South China Sea.