Journal of Tropical Oceanography ›› 2022, Vol. 41 ›› Issue (5): 189-193.doi: 10.11978/2021186CSTR: 32234.14.2021186

• Marine Biology • Previous Articles    

Antiviral chromones from the deep-sea hydrothermal-vent-derived Fusarium sp. SCSIO 06196

WANG Junfeng1, ZHOU Wenying2, TIAN Xinpeng1, LIU Yonghong1()   

  1. 1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
    2. Fifth School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
  • Received:2021-12-30 Revised:2022-03-01 Online:2022-09-10 Published:2022-03-21
  • Contact: LIU Yonghong E-mail:yonghongliu@scsio.ac.cn
  • Supported by:
    Science and Technology Project of Hainan Province(ZDKJ202018);National Natural Science Foundation of China(21502204);National Natural Science Foundation of China(41776169)

Abstract:

Six chromone derivatives (1 ~ 6) were identified from the fungus Fusarium sp. SCSIO 06196 isolated from deep-sea hydrothermal vent environments in the Western Pacific. Their structures were elucidated mainly by extensive Nuclear Magnetic Resonance (NMR) spectroscopic, mass spectrometric (MS) and rotational analysis. Antiviral activities of the compounds 1 ~ 6 were tested. Among these compounds, compounds 1 ~ 3 exhibited significant in vitro anti-enterovirus 71 (EV-71) activities with IC50 values of 26.7, 19.8, and 22.0 μmol•L-1, respectively (IC50=177 μmol•L-1, Ribavirin). In addition, compound 1 showed weak antiviral activity against the H3N2 influenza virus with IC50 value of 8.6 μmol•L-1 (IC50=18.5 nmol•L-1, Tamiflu).

Key words: deep-sea hydrothermal vent, polyketide, anti-EV 71 activity, anti-H3N2 activity

CLC Number: 

  • P735.4