中国南海来源真菌Penicillium sp. SCSIO 40438次级代谢产物研究

doi:10.11978/2022079

Journal of Tropical Oceanography ›› 2023, Vol. 42 ›› Issue (1): 161-167.doi: 10.11978/2022079CSTR: 32234.14.2022079

• Exploitation of Marine Resources • Previous Articles Next Articles

Study on the secondary metabolites of fungus Penicillium sp. SCSIO 40438 from the South China Sea

ZHU Yiguang¹^,²^,³(), MOU Pengyun¹^,⁴(), ZHANG Qingbo¹^,²^,³, ZHANG Changsheng¹^,²^,³

1. Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
2. University of Chinese Academy of Sciences, Beijing 100049, China
3. Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China
4. College of Life Science and Technology, Tarim University, Alar 843300, China

Received:2022-04-14 Revised:2022-05-08 Online:2023-01-10 Published:2022-05-10
Contact: ZHU Yiguang, email: ygzhu@scsio.ac.cn;MOU Pengyun, email: Moupengyun@163.com
Supported by:
Guangdong MEPP Funds(GDNRC[2021]48); K.C.Wong Education Foundation(GJTD-2020-12); Key Area Research and Development Program of Guangdong Province(2020B1111030005); Special Support Program for Training High Level Talents in Guangdong(2019TQ05H299)

Abstract

Abstract:

This experiment aims to study the secondary metabolites of fungus Penicillium sp. SCSIO 40438 from the South China Sea. The solid fermentation products of the strain were isolated and purified by a variety of separation methods, including silica gel column, Sephadex LH-20 gel column, and preparative high performance liquid chromatography. The structures of the isolated compounds were identified by nuclear magnetic resonance, high resolution electrospray ionization mass spectroscopy and comparison with the previously reported data. Nine compounds were obtained and identified as 1-(2-Methylbut-3-en-2-yl)-1H-indole-3-carbaldehyde (1), 1-methyl-2(1H)-quinazolinone (2), fructigenine A (3), fructigenine B (4), 2-[(s)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (5), 3-Methylviridicatin (6), 3-O-methylviridicatol (7), viridicatol (8), (+)-cyclopenol (9), and compounds 1 and 2 are two new natural products. Compound 8showed moderate antibacterial activities against Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus with minimal inhibition concentration (MIC) values of 8.0 μg·mL^-1.

Keywords fungi; Penicillium sp.; secondary metabolites; antibacterial activity

ZHU Yiguang, MOU Pengyun, ZHANG Qingbo, ZHANG Changsheng. Study on the secondary metabolites of fungus Penicillium sp. SCSIO 40438 from the South China Sea[J].Journal of Tropical Oceanography, 2023, 42(1): 161-167.

Figures/Tables 3

References 21

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化合物	M. Luteus SCSIO ML01	S. Aureus ATCC 29213	MRSA ATCC 43300	P. aeruginosa ATCC 27853	A. baumannii ATCC 19606	E.coli ATCC 25922
1	32.0	>64.0	32.0	>64.0	>64.0	>64.0
2	>64.0	>64.0	>64.0	>64.0	>64.0	>64.0
3	>64.0	>64.0	>64.0	>64.0	>64.0	>64.0
4	>64.0	>64.0	>64.0	>64.0	>64.0	>64.0
5	>64.0	>64.0	>64.0	>64.0	>64.0	>64.0
6	>64.0	>64.0	>64.0	>64.0	>64.0	>64.0
7	>64.0	>64.0	>64.0	>64.0	>64.0	>64.0
8	>64.0	8.0	8.0	>64.0	>64.0	>64.0
9	>64.0	>64.0	>64.0	>64.0	>64.0	>64.0
对照	0.5^a	0.5^a	0.5^a	1.0^b	1.0^b	1.0^b

Study on the secondary metabolites of fungus Penicillium sp. SCSIO 40438 from the South China Sea

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