海洋微生物来源天然产物研究现状与态势

doi:10.11978/2020104

Abstract

Abstract:

Because of their unique habitat and metabolic pathways, marine microorganisms can produce a variety of bioactive substances with novel structures and functions, which make natural products from these marine microorganisms become a research hotspot of new marine drugs. Combining the methods and perspectives of bibliometrics, we review in this paper the research status of natural products from marine fungi and marine bacteria, the artificial synthesis of natural products of marine microorganisms, the biological activity and druggability evaluation of natural products from marine microorganisms, to clarify the current status and development trend of natural products from marine microorganisms.

Key words: marine microorganism, natural product, marine drug, biosynthesis, biological activity evaluation

CLC Number:

P745.3

MA Lili, TIAN Xinpeng, LI Guiju, ZHAO Yanqiang, YIN Jianping. Research status and development trends of natural products from marine microorganisms[J].Journal of Tropical Oceanography, 2021, 40(5): 134-146.

Figures/Tables 6

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Research status and development trends of natural products from marine microorganisms

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	关键词	词频		关键词	词频
1	marine fungi	285	16	anticancer	33
2	Antibacterial activity	218	17	apoptosis	33
3	marine bacteria	157	18	drug discovery	29
4	cytotoxicity	131	19	Biofilm	28
5	Marine actinomycetes	131	20	genome mining	25
6	bioactivity	78	21	total synthesis	25
7	Streptomyces sp.	77	22	Diketopiperazine	21
8	antibiotics	55	23	antitumor	19
9	biosynthesis	52	24	metabolomics	19
10	antifungal activity	51	25	antioxidant	18
11	Marine sponge	51	26	pharmacology	18
12	polyketide	48	27	synthesis	17
13	Antifouling	42	28	biosynthetic gene cluster	16
14	alkaloids	41	29	peptides	16
15	structure elucidation	38	30	Polyketide synthase	16

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