海洋放线菌Actinoplanes sp. M4I6化学成分研究

doi:10.11978/2022225

Abstract

Abstract:

The secondary metabolites of marine actinomycete Actinoplanes sp. M4I6 were isolated and identified, moreover their biological activities were evaluated. The compounds were separated and purified by Silica gel, C₁₈, Sephadex LH-20 column chromatography and high performance liquid chromatography (HPLC), and their structures were identified by NMR spectroscopic method. These compounds were evaluated for anti-Bacillus subtilis (ATCC 6633) and inhibition of acetylcholinesterase activity. Nine compounds were separated and identified as (E)-prop-1-enyl-2-hydroxypropanoate(1), cyclo-(R-Pro-R-Phe)(2), cyclo-(L-Val-L-Leu)(3), cyclo-(L-Phe-L-Val)(4), cyclo-(L-Leu-L-Phe) (5), lumichrome (6), 2-(4-hydroxyphenyl)ethylacetate(7), 4-hydroxysattabacin(8), 3-hydroxybutan-2-yl 2-phenylacetate(9), compound 1 is a new natural product. Compounds 5, 6, 8 and 9 showed certain inhibitory activities against Bacillus subtilis(ATCC 6633). Compounds 4 and 6 showed weak inhibitory activities against acetylcholinesterase.

Key words: marine-derived actinomycetes, Actinoplanes sp., chemical composition, acetylcholinesterase inhibitory activity, Anti-Bacillus subtilis activity

WANG Zipeng, LI Fenfa, XIE Qingyi, MA Qingyun, YANG Li, DAI Haofu, LUO Duqiang, ZHAO Youxing. Study on the chemical constituents from the marine-derived actinomycete Actinoplanes sp. M4I6[J].Journal of Tropical Oceanography, 2023, 42(5): 38-44.

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References 30

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Study on the chemical constituents from the marine-derived actinomycete Actinoplanes sp. M4I6

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