Journal of Tropical Oceanography ›› 2025, Vol. 44 ›› Issue (1): 146-153.doi: 10.11978/2024051CSTR: 32234.14.2024051

• Exploitation of Marine Resources • Previous Articles     Next Articles

γ-Aromatic butenolides lignans from soft coral-associated symbiotic and epiphytic fungi Aspergillus terreus EGF7-0-1(I)

HE Yueming1(), ZHAO Lining2(), CHEN Xinqi1, HE Jiahong1, FAN Hao1, CHEN Leyi1, ZHANG Cuixian1(), HE Xixin1()   

  1. 1. School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
    2. Library, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
  • Received:2024-03-05 Revised:2024-03-17 Online:2025-01-10 Published:2025-02-10
  • Contact: ZHANG Cuixian, HE Xixin
  • Supported by:
    National Natural Science Foundation of China(82273845); Special Fund of Guangdong Provincial Department of Natural Resources(GDNRC[2023]37); Special Fund of Guangdong Provincial Department of Natural Resources(GDNRC[2020]039); Special Fund of Guangdong Provincial Department of Natural Resources(GDNRC[2021]048); Innovation and Entrepreneurship Program for College Students in Guangdong Province(202310572224); Innovation and Entrepreneurship Program for College Students in Guangdong Province(202310572291)

Abstract:

In order to discover the novel and bioactive secondary metabolites, the soft coral-associated symbiotic and epiphytic fungi Aspergillus terreus EGF7-0-1 were fermented in rice media. The secondary metabolites were isolated using various chromatographic technologies, yielding eight γ-aromatic butenolide lignans. Based on nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HR-ESI-MS) and comparison with the literature, their structures were determined to be butyrolactones I−V (15), aspernolide E (6), asperteretal D (7) and terrusnolide A (8). In this study, the inhibitory activity of these compounds against TDP1 (Tyrosyl-DNA phosphodiesterase 1) in vitro was studied for the first time, but it was unfortunate that compounds 18 did not show any inhibitory abilities against TDP1. This study provides theoretical data for the discovery of TDP1 inhibitors.

Key words: traditional marine Chinese medicine soft coral, Aspergillus terreus, γ-aromatic butenolides lignans, structural identification, TDP1 inhibitors

CLC Number: 

  • O629