群体感应抑制活性导向分离腐皮镰刀菌中代谢产物

doi:10.11978/2018096

Journal of Tropical Oceanography ›› 2019, Vol. 38 ›› Issue (3): 98-103.doi: 10.11978/2018096CSTR: 32234.14.2018096

• Marine Biology • Previous Articles

QSI activity-oriented isolation of metabolites from Fusarium solanum

Yubin JI¹,Zhe ZHANG¹,Weihao ZHANG²,Hu WANG²,Ying PAN³,Wei JIANG^1,²()

^1. Research Center of Life and Environment Science, Harbin University of Commerce, Harbin 150076, China
^2. School of Environmental Science and Engineering, Yangzhou 225127, China
^3. Jiangsu Cancer Hospital, Nanjing 210009, China

Received:2018-09-25 Revised:2018-11-21 Online:2019-05-20 Published:2019-06-17
Contact: Wei JIANG E-mail:weijiang@yzu.edu.cn
Supported by:
Natural Science Foundation for College and University of Jiangsu Province(15KJB170020);Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences(201707);Yangzhou University Incubation Foundation(2017CXJ050)

Abstract

Abstract:

In this study, we investigated the metabolites from coastal mud-derived fungus WH7-2 by using the quorum sensing inhibitory (QSI) activity-oriented approach. The strain WH7-2 was identified as F. solani by analyzing its morphological characteristics and internal transcribed spacer (ITS) sequence. Chemical investigation of the rice fermentation product led to the isolation of 11 compounds. Their structures were elucidated as (2E, 5E)-3, 5, 7-trimethyl-2, 5-octadienoic acid (1), mixtures of unsaturated fatty acid ester (2, 3 and 4), 3-methyl ether fusarubin (5), Anhydrofusarubin (6), (22E)-5α, 8α- epidioxy-ergosta-6, 22-diene-3β-ol(7), (22E)-5α, 8α-epidioxy-ergosta-6, 9(11), 22-triene-3β-ol (8), 3β-hydroxycholest-5-en-7-one(9), 6β-hydroxy-cholest-4-en-3-one(10), and (22E)-cholest-5, 22-dien-3β-ol(11). All compounds were evaluated for their QSI activities, and only the mixtures of unsaturated fatty acid ester (2-4) exhibited QSI activity. All the compounds except 5 and 6 were first reported from F. solani.

Key words: QSI, Fusarium solani, unsaturated fatty acid ester, steroid, fusarubin

CLC Number:

Q935

Yubin JI,Zhe ZHANG,Weihao ZHANG,Hu WANG,Ying PAN,Wei JIANG. QSI activity-oriented isolation of metabolites from Fusarium solanum[J].Journal of Tropical Oceanography, 2019, 38(3): 98-103.

Figures/Tables 2

References 16

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化合物编号	保留时间/min	分子式	分子量	名称	匹配度/℅
2	22.4	C₁₇H₂₈O₂	264	Methyl 7,10,13-hexadecatrienoate	85.3
3	23.1	C₁₇H₂₈O₂	264	Methyl 8,11,14-hexadecatrienoate	89.2
4	24.5	C₁₈H₃₀O₂	278	ethyl 6,9,12-hexadecatrienoate	95.3

QSI activity-oriented isolation of metabolites from Fusarium solanum

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