北部湾柱状角孔珊瑚水螅体次级代谢产物研究

doi:10.11978/2023058

Abstract

Abstract:

In order to investigate the secondary metabolites in hydranth of coral Goniopora columna, the ethanol extracted products were isolated and purified by silica gel column chromatography, Sephadex LH-20 gel column chromatography and semi-preparative high-performance liquid chromatography (HPLC). Their structures were identified by modern spectral technology. Meanwhile, the cytotoxicities of 1 ~ 8 were tested against anti-non-small cell lung cancer A549 cells (NSCLC) lines. As a result, a new alkaloid 1 and seven known compounds 2 ~ 8 were isolated and identified as alkalgoniopora A (1), theophylline (2), thymine deoxyribonucleoside (3), uracil (4), thymine (5), pregna-5, 20-dien-3β-ol (6), cinnamic acid (7) and protocatechuic acid (8). Among them, compounds 1, 2 and 6 had weak inhibitory activity on the proliferation of NSCLC, while other compounds had no obvious inhibitory activity on the proliferation of NSCLC. This investigation provides a reference basis for the study of metabolites and exploration of medicinal activity in hydranth of coral Goniopora columna.

Key words: Goniopora columna, hydranth, secondary metabolites, non-small cell lung cancer A549 cells (NSCLC)

FENG Guangfu, HE Jeyi, BAI Meng, YI Xiangxi, LIU Xinming, LUO Lianxiang, GAO Chenghai. Secondary Metabolites from Hydaranth of Coral Goniopora columna in the Beibu Gulf[J].Journal of Tropical Oceanography, 2024, 43(2): 135-139.

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References 15

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No.	1 (Pyridine-d₅)		2 (CDCl₃)
No.	δ_H(Mult, J in Hz)	δ_C(Mult)	δ_H(Mult, J in Hz)	δ_C(Mult)
2	8.27, s, 1H	140.9, CH	8.01, s, 1H	140.4, CH
4	-	149.2, C	-	148.1, C
6	-	152.5, C	-	151.4, C
8	3.54, s, 3H	28.5, CH₃	3.23, s, 3H	27.4, CH₃
9	-	155.9, C	-	154.4, C
10	-	108.4, C	-	106.4, C
11	3.67, m, 2H	30.5, CH₂	3.43, m, 3H	29.4, CH₃
12	1.29, m, 2H	23.4, CH₂	-	-
13~23	1.41~1.13, m, 20H	35~23 [CH₂]₁₀	-	-
24	0.89, s, 3H	14.8, CH₃	-	-

Secondary Metabolites from Hydaranth of Coral Goniopora columna in the Beibu Gulf

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