海洋链霉菌Streptomyces sporoverrucosus 33510次级代谢产物研究

doi:10.11978/2023080

Abstract

Abstract:

The secondary metabolites of marine actinomycete Streptomyces sporoverrucosus 33510 were studied in order to obtain bioactive compounds. The compounds were separated and purified by column chromatography, semi-preparative liquid chromatography and other chromatographic methods. Ten compounds were identified as cyclo(D-Pro-D-Leu) (1), bisphenol A (2), methylp-hydroxyphenylacetate (3), N-phenethylacetamide (4), 3-indole-methylethanoate (5), dibutyl phthalate (6), cyclo(D-Pro-L-Leu) (7), cyclo(D-Pro-L-Ile) (8), cyclo(L-Pro-L-Phe) (9), and cyclo(L-Leu-L-Val) (10). Eight compounds were isolated from Streptomyces sporoverrucosus for the first time. Compound 2 showed inhibitory activity against Cryphonectria parasitica.

Key words: Streptomyces sporoverrucosus 33510, secondary metabolites, antibacterial activity

LIU Ying, XIAO Yang, ZHU Zhenxin, LIU Hongcun, JIANG Mingguo, ZHU Yuzhang, LIN Kun, WU Jincheng, LU Xiaomei, HUANG Xiaoning, LIANG Haina, LU Wensen, YANG Lifang. Study on the Secondary Metabolites of Marine Streptomyces Sporoverrucosus 33510[J].Journal of Tropical Oceanography, 2024, 43(2): 128-134.

Figures/Tables 8

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References 15

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时间/min	甲醇/%	水/%
0.01	10	90
5	10	90
15	100	0
20	100	0
25	10	90

名称	直径/mm	抑菌效果
Fusarium oxysporum	10	√
Fusarium pseudograminearum	22	√
Colletotrichum musae	16	√
Rhizoctonia solani	18	√
Plectosphaerella cucumerina	0	×
Cryphonectria parasitica	0	×
Botryosphaeria dothidea	20	√
Bipolaris sorokiniana	20	√

化合物	抑菌强度	直径/mm	病原菌
2	高敏	20	Cryphonectria parasitica
3	耐药	0	Rhizoctonia solani、Fusarium pseudograminearum
4	耐药	0	Rhizoctonia solani
5	耐药	0	Rhizoctonia solani
6	耐药	0	Rhizoctonia solani
7	耐药	0	Cryphonectria parasitica、Fusarium pseudograminearum
9	耐药	0	Cryphonectria parasitica

直径/mm	抑菌性
>20	极敏
15~20	高敏
10~14	中敏
<10	低敏
0	耐药

Study on the Secondary Metabolites of Marine Streptomyces Sporoverrucosus 33510

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