南海礁栖海藻共附生真菌Pestalotiopsis neglecta SCSIO41 403次级代谢产物研究

doi:10.11978/2021089

Abstract

Abstract:

We research on the secondary metabolites from the fungus Pestalotiopsis neglecta SCSIO41403, derived from the coral reefs habitat algae Coelarthrum sp. in the South China Sea. Six pure secondary metabolites were isolated and purified by medium pressure normal phase column chromatography and semi-preparative high performance liquid chromatography (HPLC) in the fungal culture broth. The compounds were identified and elucidated as gamahorin (1), microsporaline C (2), 7-hydroxy-5-methoxy-4,6-dimethylphthalidc (3), demethyl nectriapyrone A (4), 4-hydroxybenzaldehyde (5), 4-hydroxyphenethyl acetate (6) by nuclear magnetic resonance spectrum (NMR), mass spectrum (MS), and literature analysis. All compounds were obtained from this strain for the first time, and compounds 1, 2, 5, and 6 were discovered from marine-derived fungus for the first time. In the antibacterial tests, compound 3 was revealed to have significant inhibitory activity against Candida albicans.

Key words: Algae-derived fungus, Pestalotiopsis neglecta, secondary metabolites, antibacterial activity, South China Sea

CLC Number:

Q935

YE Yuxiu, LUO Xiaowei, YANG Bin, LIN Xiuping, LIU Yonghong, ZHOU Xuefeng. Study on the secondary metabolites of reef habitat algae-derived fungus Pestalotiopsis neglecta SCSIO41403 from the South China Sea[J].Journal of Tropical Oceanography, 2022, 41(3): 186-190.

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References 14

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Study on the secondary metabolites of reef habitat algae-derived fungus Pestalotiopsis neglecta SCSIO41403 from the South China Sea

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