海绵共附生真菌Penicillium crustosum SCSIO 41442活性代谢产物研究

doi:10.11978/2025025

Bioactive Metabolites from the Sponge-Derived Fungus Penicillium crustosum SCSIO 41442

LIANG Jiaqi^{1, 2}, CHEN Xinqi^{1, 2}, CHEN Yi^{1, 2}, CONG Mengjing¹, CAO Qinlin¹, HUANG Xiaowen^{1, 3}, LIU Yonghong¹, JAYASINGHE Lalith^{1, 4}, CHEN Chunmei¹, ZHOU Xuefeng^{1, 2}

1. CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;

2. University of Chinese Academy of Sciences, Beijing 100049, China;

3. Pharmacy school of Guilin Medical University, Guilin 541199, China;

4. National Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka

Received:2025-02-18 Revised:2025-03-19 Accepted:2025-03-25
Supported by:
Special Project for Marine Economic Development of Department of Natural Resources of Guangdong Province(GDNRC[2023]37)

Abstract

Abstract: A new alkaloid, diacedolinate (1), together with 15 known compounds (2–16) were isolated from sponge–associated fungus Penicillium crustosum SCSIO 41442. The structure of these compounds was determined by spectrum analysis and ECD (electronic circular dichroism). All compounds were tested for their antioxidant and antimicrobial activities. As the result, compound 1 showed remarkable antioxidant activity with IC50 (half maximal inhibitory concentration) value of 71.00 μg/mL. Compound 2 displayed extensive antioxidant activity with IC50 value of 1.25 μg/mL, compared with the positive control, Vitamin C. In addition, compounds 9, 10, 11 and 16 demonstrated broad antimicrobial activity against a variety of pathogens, including MRSA (methicillin-resistant Staphylococcus aureus), Colletotrichum asianum HNM 408, Colletotrichum acutatum HNM RC178 and Alternaria alternate, with MIC (minimum inhibitory concentration) values between 2.5 and 160 μg/mL. The activity of these compounds was reported for the first time.

Key words: sponge-derived fungi, Penicillium crustosum, secondary metabolites, antioxidant, antimicrobial

LIANG Jiaqi CHEN Xinqi CHEN Yi CONG Mengjing CAO Qinlin HUANG Xiaowen LIU Yonghong JAYASINGHE Lalith CHEN Chunmei ZHOU Xuefeng. Bioactive Metabolites from the Sponge-Derived Fungus Penicillium crustosum SCSIO 41442[J].Journal of Tropical Oceanography, 0, (): 1-.

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Bioactive Metabolites from the Sponge-Derived Fungus Penicillium crustosum SCSIO 41442

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