北部湾软珊瑚共附生真菌Scopulariopsis sp. SCSIO 41229次级代谢产物研究

doi:10.11978/2024184

Study on the secondary metabolites of the soft coral-derived fungus Scopulariopsis sp. SCSIO 41229 from the Beibu Gulf

HE Yanchun^{1, 2}, XU Shuna^{1, 2}, LIU Yonghong¹, YANG Bin¹

1. Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;

2. University of Chinese Academy of Sciences, Beijng 100049, China

Received:2024-09-29 Revised:2024-12-02 Accepted:2024-12-12
Contact: Yang, Bin
Supported by:
National Natural Science Foundation of China (42276128)

Abstract

Abstract: In this study, we aim to investigate the secondary metabolites from the coral-derived fungus Scopulariopsis sp. SCSIO 41229, which were collected from the Beibu Gulf. The secondary metabolites were isolated by silica gel column chromatography, reverse phase silica gel column chromatography, thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC). The chemical structures of these compounds were identified by nuclear magnetic resonance (NMR), mass spectrometry (MS) and literature analysis. Nine known compounds were isolated and elucidated as neocyclocitrinols A–D (1~4), penicillenol A2 (5), cyclo-(D-Phe-L-Ile) (6), cyclo-(L-tryptophyl-L-phenylalanyl) (7), 2-(hept-5-enyl)-3-methyl-4-oxo-6,7,8,8a-tetrahydro-4H-pyrrolo[2,1-b]-1,3-oxazine (8), (8E,10E)-7-oxo-8,10-heptadecadienoic acid (9). Bioassays indicated that compounds 2, 4 had weak antioxidant activity and compounds 1, 4, 8 showed weak inhibitory activity against acetylcholin esterase. Compounds 1~9 were obtained from the fungus Scopulariopsis sp. for the first time.

Key words: coral-derived fungus, secondary metabolites, Scopulariopsis sp.

HE Yanchun XU Shuna LIU Yonghong YANG Bin. Study on the secondary metabolites of the soft coral-derived fungus Scopulariopsis sp. SCSIO 41229 from the Beibu Gulf[J].Journal of Tropical Oceanography, 0, (): 1-.

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Study on the secondary metabolites of the soft coral-derived fungus Scopulariopsis sp. SCSIO 41229 from the Beibu Gulf

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