涠洲岛海洋沉积物来源真菌Aspergillus sp. GXIMD02003的代谢产物研究

doi:10.11978/2022232

Abstract

Abstract:

To explore the diversity of secondary metabolites of fungus Aspergillus sp. GXIMD02003 derived from marine sediment, its secondary metabolites were separated based on the various chromatographic techniques. Chemical structures were identified using mass spectroscopy, nuclear magnetic resonance spectroscopy, and optical rotation combined with comparison of literature data. Eight compounds were isolated from Aspergillus sp. GXIMD02003, and identified as (3S, 11aS)-3-[(1H-indol-3-yl)methyl]-7, 9-dihydroxy-8-methoxy-2,3,11,11a-tetrahydro-6H-pyrazino[1,2-b]isoquinoline-1,4-dione (1), cyclo(L-Pro-L-Tyr) (2), cyclo(L-4-Hyp-D-phe) (3), cyclo(L-4-Hyp-L-Phe) (4), cyclo(L-4-Hyp-L-leucine) (5), cyclo(L-4-Hyp-D-leucine) (6), desmethyldiaportinol (7), 2-(2ʹ-hydroxypropyl)-5-methyl-7-hydroxychromone (8). Compounds 1~8 showed no inhibitory activities against cancer cell proliferation, α-glucosidase and pathogenic bacteria at testing concentration. Compounds 1~8 were isolated from fungus derived from marine sediment of the Weizhou island for the first time. The project enriched the diversity of secondary metabolites from Aspergillus sp. GXIMD02003, laid a foundation for exploring the bioactivity of fungal secondary metabolites from marine sediment in the Weizhou island.

Key words: marine fungus, Aspergillus, secondary metabolites, marine sediment, Weizhou Island

XING Nannan, REN Runxin, TANG Zhenzhou, LUO Zhihong, XIA Chenxi, LIU Yonghong, PENG Liang, CHEN Xianqiang. Study on the secondary metabolites of fungus Aspergillus sp. GXIMD02003 derived from marine sediment in the Weizhou island[J].Journal of Tropical Oceanography, 2023, 42(5): 154-160.

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References 27

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Study on the secondary metabolites of fungus Aspergillus sp. GXIMD02003 derived from marine sediment in the Weizhou island

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